Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Vaccine effectiveness and duration of protection against symptomatic infections and severe Covid-19 outcomes in adults aged 50 years and over, France, January to mid-December 2021Research article Published on 2022-12-012022-10-05 Journal: Global Epidemiology [Category] 변종, [키워드] Analysis booster booster dose COVID-19 database deaths decrease delta variant Effectiveness ENhance Evolution finding France Hospitalization hospitalizations ICU admission infected individuals information National outcome performed Real-world estimates reduced remained reversed SARS-CoV-2 Spread survival symptomatic symptomatic infection symptomatic infections test-negative design vaccination Vaccine vaccine immunity variant variants waning immunity [DOI] 10.1016/j.gloepi.2022.100076 [Article Type] Research article
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 보세프레비르 기반 주요 프로테아제 억제제의 체계적인 탐색Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 293T cell 293T cells active site Alanine aldehyde amide Antiviral antiviral potency boceprevir Carbamate carbamide changed characterized complex covalent inhibitor COVID-19 crystal structure crystal structures cysteine cytotoxicity expressed HCV hydrophobic hydrophobic interaction IMPROVE in vitro inhibit inhibitor inhibitors isovaleramide M pro main protease Modification modifications N-terminal nitrile observation Opal PF-07321332 Pro protease Protease inhibitor recognize residue reversed SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variants SARS-CoV-2. side chain substrate tested the SARS-CoV-2 undetectable unique warhead [DOI] 10.1016/j.ejmech.2022.114596 PMC 바로가기 [Article Type] Article
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived VesiclesArticle Published on 2022-09-232022-11-16 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] airway epithelial cells anti-apoptotic approach BCl2 BCL2 antagonist/killer caused cell death cell-free mitochondrial DNA changes co-culture co-cultured COVID-19 COVID-19 patient Effect Effects epithelial cells functional induce inhibit Inner Interaction intercellular intercellular mitochondrial transfer knockdown MCL1 mechanism membrane vesicle mitigate mitochondrial mitochondrial DNA Mortality MSC MSCs myeloid cell myeloid cell leukemia-1 nsp4 Orf9b outer membrane overexpression plasma pro-apoptotic pro-inflammatory Protein Release reversed SARS-CoV-2 SARS-CoV-2 protein screened significantly stem cell therapeutic Therapeutic approach these cell transfer Treatment tunneling nanotubes. [DOI] 10.3390/cells11192969 PMC 바로가기
Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosisArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] acute injury Analysis analyzed article changed Cluster collected Comorbidities coronavirus 2 coronavirus disease country COVID-19 COVID-19 pandemic Cystic database Diagnosis early phase English enrolled Epidemiology etiology Evidence experiment fibrosis French hotspot hotspots and trends Imperial College London Increasing individual level Infection international cooperation intrinsic investigated journal Laboratory Lung function material novel Pathogenesis Patient professional promote public health threat Quality of life Research reversed Spread Therapies therapy Therapy. university University of Washington USA vaccination Volume was performed Web of Science [DOI] 10.3389/fpubh.2022.967829 PMC 바로가기
Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on ErythropoiesisArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] SARS, 변종, [키워드] ACE2 Affect Blood blood circulation Bone marrow CD45 CD8 Cell COVID-19 patient COVID-19 patients degranulation Delta disease severity dominant erythropoiesis erythropoiesis. Express expressing expression Frequency function functions granzyme hallmark Hematopoiesis hypoxia immature immunosuppressive immunosuppressive properties Impact impair in vitro investigated omicron oxygen Patient prevalent provide RBC RBCs reactive oxygen specy receptor red blood cell reversed ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly strain subpopulation suppress T cell the SARS-CoV-2 these cell tissues TMPRSS2 Transmissibility variant variants Wuhan Wuhan strain [DOI] 10.1128/spectrum.01730-22 PMC 바로가기
Antibody-Mediated Immunogenicity Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Following Priming, Boosting, and Hybrid Immunity: Insights From 11 Months of Follow-up of a Healthcare Worker Cohort in Israel, December 2020-October 2021프라이밍, 부스팅 및 하이브리드 면역에 따른 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 항체 매개 면역원성: 이스라엘 의료 종사자 집단의 11개월 추적 관찰에서 얻은 통찰력, 2020년 12월-2021년 10월Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome Against age all age group all age groups anti-S Antibody titer Breakthrough infection circulating Cohort comparable coronavirus coronavirus 2 coronavirus disease COVID-19 decrease described dose doses geometric mean concentration GMC HCW HCWs healthcare worker highlight hybrid IgG IgG level IgG levels IgG titer Immunity immunogenicity Immunoglobulin individual infected individual infected individuals Infection initial insight Israel Month participant PCR polymerase chain proportion Protective Quantitative re-infected Reinfection remained respiratory reversed S1/S2 SARS-CoV-2 subsequent tested timepoint uninfected vaccination Vaccine vaccine immunogenicity Vaccines Vaccines. waned worker [DOI] 10.1093/cid/ciac212 PMC 바로가기 [Article Type] Article
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
Untargeted lipidomics reveals specific lipid profiles in COVID-19 patients with different severity from Campania region (Italy)비표적 지질학은 캄파니아 지역(이탈리아)과 중증도가 다른 COVID-19 환자의 특정 지질 프로필을 보여줍니다Article Published on 2022-08-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome alteration applied approaches blood sample Blood samples Campania cause Ceramides characterized clinical phenotype Cohort collected comparable contrary Control controls correspondence COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset decrease disease dysregulation highlight Hospital admission increase in Infection Italian Italy Lipid Lipidomics Liquid chromatography longitudinal population mass spectrometry Mild Modification MONITOR outcome Patient patients platform Potential biomarker predict profile respiratory reveal reversed Severe acute respiratory syndrome severe patients severity significantly subset TGs trajectory Trapped ion mobility UHPLC Untargeted. [DOI] 10.1016/j.jpba.2022.114827 PMC 바로가기 [Article Type] Article
Variations of COVID-19 mortality are affected by economic disparities across countriesCOVID-19 사망률의 변화는 국가 간 경제적 격차에 영향을 받습니다.Article Published on 2022-08-012022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, [키워드] Affect affected average mortality Case fatality rate case fatality rates CFRs Clinical outcome clinical outcomes country COVID-19 COVID-19 case COVID-19 disease COVID-19 mitigation COVID-19 mortality cross-sectional cross-sectional study cumulative Dashboard death decreasing dominant Economy Efficiency exhibited Factor Factors First wave health system income Income levels increase in increased mortality management maximum medical resource Mitigation Mortality mortality rate mortality rates much lower outcome patients performed Policy population density populations Prevent reduction Region reported reversed second wave situation Stage the disease time lag Transmission Turning Turning points unit variant Wave Waves Waves. WHO Worldometer [DOI] 10.1016/j.scitotenv.2022.154770 PMC 바로가기 [Article Type] Article